Change 19: Overall Response Table, Subjects Without Measurable Disease

RECIST 1.0:

RECIST 1.0 has no specific recommendations. Perceptive has defined modifications for this topic according to our experience and current scientific knowledge.

RECIST 1.1:

Non-target	New	Overall Response
CR	No	CR
Non-CR / non-PD	No	Non-CR / non-PD
Not all evaluated	No	NE
Unequivocal PD	Yes or No	PD
Any	Yes	PD

*“Non-CR/non-PD is preferred over “stable disease” for non-target disease since SD is increasingly used as an endpoint for assessment of efficacy in some trials so to assign this category when no lesions can be measured is not advised.